Ensure Plus

Ensure Plus is a nutritionally complete oral supplement designed to deliver concentrated calories and protein for patients who need to gain or maintain healthy weight [2]. Each 8-fl-oz bottle of the chocolate shake provides 350 calories, with 44% more protein and 45% more calories than Ensure Regular [1][3], along with 27 vitamins and minerals [3]. The formula derives its protein from milk and soy [4], which are relatively low-purine sources compared to meat or shellfish — a point in its favor for gout management, since dairy protein has been linked to lower serum urate.

The main concern for gout patients is the added sugar content. Sucrose and corn syrup solids in the formula are roughly half fructose, and fructose metabolism directly generates uric acid while also promoting insulin resistance, which can impair urate excretion. Regular use could therefore counteract any benefit from the protein source.

Practical guidance

• Use Ensure Plus occasionally as a meal supplement, not as a daily beverage, especially if you have elevated uric acid or frequent flares.
• Watch total portions: each 200–237 ml bottle packs 300–350 calories, so overuse can drive weight gain — a key gout risk factor [1][2].
• If you need weight gain or are struggling with malnutrition and gout, discuss whether a lower-sugar supplement or adjusting your gout medication is the better approach.

Ultimately, Ensure Plus is acceptable in moderation for most gout patients, but its sugar load means it should not be a routine staple.